Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors
نویسندگان
چکیده
منابع مشابه
Metabotropic glutamate receptors inhibit microglial glutamate release
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential feedback of glutamate on this system. Several agonists of mGluRs (metabotropic glutamate receptors) were applied to primary rat microglia, and the ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2008
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.2008.05426.x